Analysis Note

ControlRat olfactory bulb tissue

Application

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Neurexin-1-beta in human cerebellum, rat frontal lobe, and human thalamus tissues.

Western Blotting Analysis: A representative lot detected Neurexin-1-beta in COS cell lysates transiently transfected with Flag-tagged Neurexin-1-beta, and demonstrated a loss of signal in COS cell lysates transiently transfected with Flag-tagged Neurexin-1-alpha or untagged Kv2.1 plasmids (Prof. J. Trimmer, University of California, Davis.).

Research CategoryNeuroscience

Anti-Neurexin-1-Beta Antibody is a highly specific mouse monoclonal antibody, that targets Neurexin 1 & has been tested in IHC.

Research Sub CategoryDevelopmental Neuroscience

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Neurexin-1-beta or Neurexin I-beta is a neuronal cell surface protein thought to be involved in cell recognition and cell adhesion through the formation of intracellular junctions via binding to neuroligins. Neurexin-1-beta may also have roles in the formation and maintenance of synaptic junctions, mediation of intracellular signaling, and angiogenesis.

Immunogen

Linear peptide corresponding to the N-terminus of human Neurexin-1-beta.

Epitope: N-terminus within the extracellular domain

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Protein G Purified

Format: Purified

Quality

Evaluated by Immunohistochemistry in rat olfactory bulb tissue.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected Neurexin-1-beta in rat olfactory bulb tissue.

Specificity

This antibody recognizes the N-terminus within the extracellular domain of Neurexin-1-beta. This antibody does not cross-react with Neurexin1-alpha or Neurexin-2 (Prof. J. Trimmer, University of California, Davis.).

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

47 kDa calculated. This protein has been observed at ~70 kDa (Prof. J. Trimmer, University of California, Davis.). Uncharacterized band(s) may be observed in some cell lysates.